Two sample MR report
TTC39C_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0389953 | 0.0882873 | 0.6886141 |
| Weighted median | 5 | 0.0274195 | 0.0100796 | 0.0065221 |
| Inverse variance weighted | 5 | 0.0277376 | 0.0085241 | 0.0011379 |
| Simple mode | 5 | 0.0273035 | 0.0140990 | 0.1248703 |
| Weighted mode | 5 | 0.0279854 | 0.0131695 | 0.1007707 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9825081 | 3 | 0.8054844 |
| Inverse variance weighted | 0.9989206 | 4 | 0.9099596 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0083727 | 0.0653551 | 0.9061664 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.54e-05 | 0 | TRUE | 0.481724 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
